Shunichi Shimizu Selected Research

lomerizine

1/2014	Influence of the Tohoku-Pacific Ocean earthquake and its aftershocks on the response to prophylactic therapy with lomerizine in patients with migraine in Tokyo: a retrospective study.
12/2013	Characteristics of inconsistent responders to prophylaxis therapy with lomerizine in patients with migraine: a retrospective study in Japan.
12/2011	Neuroprotection by lomerizine, a prophylactic drug for migraine, against hydrogen peroxide-induced hippocampal neurotoxicity.
10/2009	Inhibitory effect of lomerizine, a prophylactic drug for migraines, on serotonin-induced contraction of the basilar artery.

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Shunichi Shimizu Research Topics

Disease

8	Migraine Disorders (Migraine) 01/2014 - 06/2009
5	Inflammation (Inflammations) 09/2016 - 07/2008
3	Headache (Headaches) 01/2014 - 06/2009
2	Ischemic Stroke 01/2019 - 12/2011
2	Reperfusion Injury 01/2019 - 09/2016
2	Cerebral Hemorrhage 09/2016 - 11/2015
2	Pancreatic Neoplasms (Pancreatic Cancer) 12/2015 - 03/2015
2	Secondary Headache Disorders 12/2013 - 12/2012
2	Hypersensitivity (Allergy) 01/2011 - 12/2006
2	Infarction (Infarctions) 05/2010 - 02/2006
2	Myocardial Infarction 05/2010 - 02/2006
1	Brain Ischemia (Cerebral Ischemia) 01/2019
1	Cerebral Infarction 09/2016
1	Pneumonia (Pneumonitis) 01/2016
1	Neutropenia 12/2015
1	Brain Injuries (Brain Injury) 11/2015
1	Hypoxia (Hypoxemia) 01/2014
1	Hyperoxia 01/2014
1	Cardiomegaly (Heart Hypertrophy) 03/2013
1	Fibrosis (Cirrhosis) 03/2013
1	Migraine without Aura (Common Migraine) 12/2012
1	Eosinophilia 01/2011
1	Migraine with Aura (Familial Hemiplegic Migraine) 01/2010
1	Epilepsy (Aura) 01/2010
1	Headache Disorders (Headache Syndromes) 06/2009
1	Colitis 07/2008
1	Infections 07/2008
1	Atopic Dermatitis (Atopic Eczema) 12/2006
1	Food Hypersensitivity (Food Allergy) 12/2006
1	Ischemia 02/2006
1	Neoplasms (Cancer) 02/2002

Drug/Important Bio-Agent (IBA)

4	Pharmaceutical PreparationsIBA 01/2019 - 10/2009
4	lomerizineIBA 01/2014 - 10/2009
3	Reactive Oxygen Species (Oxygen Radicals)IBA 09/2016 - 07/2008
2	ChemokinesIBA 09/2016 - 07/2008
2	Gemcitabine FDA Link 12/2015 - 03/2015
2	Nitric Oxide Synthase (NO Synthase)IBA 05/2010 - 02/2006
2	sapropterin (tetrahydrobiopterin)FDA Link 05/2010 - 02/2006
2	triphenyltetrazoliumIBA 05/2010 - 02/2006
2	Serotonin (5 Hydroxytryptamine)IBA 01/2010 - 10/2009
1	Duloxetine Hydrochloride (Cymbalta)FDA Link 01/2019
1	Hydroxyl RadicalIBA 09/2016
1	EdaravoneIBA 09/2016
1	Antineoplastic Agents (Antineoplastics)IBA 01/2016
1	Adenosine Diphosphate Ribose (ADP-Ribose)IBA 01/2016
1	Bleomycin (Blenoxane)FDA LinkGeneric 01/2016
1	Indicators and Reagents (Reagents)IBA 12/2015
1	Heme (Haem)IBA 11/2015
1	AdiponectinIBA 02/2014
1	TRPC6 Cation ChannelIBA 01/2014
1	Tryptophan HydroxylaseIBA 12/2013
1	Tryptophan (L-Tryptophan)FDA Link 12/2013
1	Metalloproteases (Metalloproteinases)IBA 03/2013
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2012
1	Monoamine Oxidase (MAO)IBA 04/2012
1	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA 04/2012
1	Lymphotoxin-alpha (Lymphotoxin)IBA 04/2012
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 12/2011
1	AllergensIBA 01/2011
1	EnzymesIBA 05/2010
1	GTP Cyclohydrolase (GTP Cyclohydrolase I)IBA 05/2010
1	5-HT2A Serotonin Receptor (5 HT2A Receptor)IBA 01/2010
1	Nonprescription Drugs (Patent Medicines)IBA 06/2009
1	Dextran SulfateIBA 07/2008
1	Interleukin-4 Receptors (Interleukin 4 Receptor)IBA 12/2006
1	Immunoglobulin E (IgE)IBA 12/2006
1	InterleukinsIBA 12/2006
1	CytokinesIBA 12/2006
1	Interleukin-10 (Interleukin 10)IBA 12/2006
1	NG-Nitroarginine Methyl Ester (L-NAME)IBA 02/2006
1	5-hydroxydecanoic acidIBA 02/2006
1	KATP ChannelsIBA 02/2006
1	NitritesIBA 02/2006
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 02/2006
1	NitratesIBA 02/2006
1	mitochondrial K(ATP) channelIBA 02/2006
1	Transcription Factors (Transcription Factor)IBA 02/2002
1	Peptide Hydrolases (Proteases)FDA Link 02/2002

Therapy/Procedure

5	Therapeutics 01/2019 - 12/2013
2	Drug Therapy (Chemotherapy) 12/2015 - 03/2015
2	Ligation 05/2010 - 02/2006
1	Self Medication 06/2009
1	Intravenous Administration 02/2006